Meta-analysis of randomised trials
A 2017 meta-analysis concluded that intragastric botulinum toxin was not effective for weight loss compared with placebo.
Vivid Clinic stopped offering gastric botox in 2025. We now recommend discussing a gastric balloon or another option with our medical team instead. This guide explains what gastric botox is, what the evidence shows and its risks.
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Editorially reviewed by the Vivid Clinic Surgical Board · Last reviewed September 2026

During an upper endoscopy, a doctor injects small amounts of botulinum toxin type A into the muscle of parts of the stomach wall. The aim is to slow emptying so you feel full sooner. Botulinum toxin is not approved by major regulators for weight loss, so this use is off-label.

| Availability at Vivid Clinic | Not offered since 2025; alternatives are reviewed free |
|---|---|
| Procedure time | About 20–30 minutes |
| Anaesthesia | Sedation (no general anaesthesia, no incisions) |
| Hospital stay | Day case, with a short observation period |
| Back to desk work | Usually the next day |
| Exercise | Light activity the next day; normal exercise within a few days |
| When the effect starts | Typically within one to two weeks |
| Effect lasts | Usually around 3–6 months |
| Expected result | Modest and variable; strongly dependent on diet |
| Regulatory status | Off-label use of botulinum toxin for weight loss |
| Stitches | None |
Vivid Clinic does not offer gastric botox. With a BMI of about 30–40, ask us about a gastric balloon. With a BMI of 40, or 35 with a weight-related illness, a gastric sleeve may suit you. Check your number with our free BMI calculator.
Research into gastric botox is small-scale and inconsistent. It may help some people feel full sooner for a few months, but it is not a proven weight-loss treatment. Most of the change comes from the diet plan that accompanies it.
A 2017 meta-analysis concluded that intragastric botulinum toxin was not effective for weight loss compared with placebo.
Some later studies, often using higher doses or different injection sites, reported reduced appetite and modest weight loss. The trials were small and their methods varied.
A 2023 overview of systematic reviews highlighted the low quality and conflicting nature of the evidence.
Vivid Clinic stopped offering gastric botox in 2025. We now point patients towards options with stronger evidence, such as a gastric balloon.
It is not surgery: nothing is removed, stapled or rerouted. Where it is offered, it is typically done in a hospital endoscopy unit with monitoring. Vivid Clinic no longer performs it.
History, medicines and BMI are typically checked first.
Usually no food for around eight hours beforehand.
Sedation is given through a cannula, with monitoring.
A thin camera passes through the mouth into the stomach.
Measured doses are placed into the stomach muscle layer.
One to two hours of rest while sedation wears off.
The review covers the options we offer, such as a gastric balloon or a gastric sleeve. It does not cover gastric botox.
Step 1
Share your height, weight, medical history and medications, here or by WhatsApp.
Step 2
Our medical team reviews your BMI and health, and whether a non-surgical or surgical option suits you.
Step 3
A gastric balloon suits a BMI of about 30–40. A gastric sleeve suits a BMI of 40+, or 35+ with a weight-related illness.
Step 4
If an option suits you, you receive a plan. A balloon usually means 3–4 days in Istanbul; a sleeve about seven.
Share your height, weight, medical history and medications. Our medical team tells you whether a gastric balloon, a gastric sleeve or another approach suits you. Free, no obligation.
Most people feel normal within a day or two. Any effect on appetite is temporary, so the habits you build during that window matter most.
Results are modest and vary widely. Some people eat smaller portions and lose some weight; others notice little difference.
For more substantial weight loss, a gastric balloon in Istanbul or a gastric sleeve is generally more effective. Both are offered at Vivid Clinic.
In short: both are non-surgical and temporary. A gastric balloon has stronger evidence for weight loss, and it is the option Vivid Clinic offers.
| Criterion | Gastric botox | Gastric balloon |
|---|---|---|
| Offered at Vivid Clinic | No, not since 2025 | Yes |
| Surgery or incisions | None; a day-case endoscopy | None; non-surgical |
| Evidence for weight loss | Limited and mixed | Stronger than for gastric botox |
| How long it works | Usually around 3–6 months | Temporary; balloon removed or passed after several months |
| First days | Sore throat, bloating, mild nausea | More nausea in the first days |
| Role | Possible short-term support to a diet plan | Generally more effective for more substantial weight loss |
For higher BMIs, a gastric sleeve or gastric bypass in Istanbul gives the most substantial and lasting results. Prescription GLP-1 medicines have much stronger trial evidence than gastric botox; discuss them with your own doctor. Compare the gastric balloon in detail.
Vivid Clinic no longer offers gastric botox, so there is no gastric botox quote. Instead, ask us about a gastric balloon in Istanbul or a gastric sleeve in Istanbul. See every option on our weight loss and bariatrics page.
What we look at:
Which alternative fits depends on
Gastric botox is less invasive than surgery, but it is not without risk. In 2023, the WHO and European health agencies reported botulism cases in people who had intragastric botulinum toxin for obesity in Türkiye. Anyone considering it should know this.
Read the WHO Europe notice on iatrogenic botulism. If you ever develop swallowing, speech, vision or breathing problems after treatment, seek emergency care immediately.
No. Vivid Clinic stopped offering gastric botox in 2025, and we do not arrange it for patients. The evidence for weight loss is limited and mixed. In 2023, the WHO and European agencies also reported botulism cases after intragastric botulinum toxin in Türkiye. We now point patients to better-studied options, such as a gastric balloon or a gastric sleeve. Our medical team reviews your details for free and tells you honestly which, if any, suits you.
The honest answer is that the evidence is mixed. Some studies report reduced appetite and modest weight loss, while a 2017 meta-analysis of randomised trials found no significant benefit over placebo. Results vary with dose, injection sites and, above all, diet. Gastric botox in Turkey should be seen as a possible short-term support to a structured nutrition plan, not a stand-alone weight-loss treatment.
Yes. Botulinum toxin is licensed for conditions such as muscle spasm and certain cosmetic uses, but no major regulator has approved it for weight loss. Using it inside the stomach for obesity is therefore off-label. That is legal when a doctor judges it appropriate and you give informed consent. You should still understand the limited evidence and the risks first.
Mild effects are common in the first days after gastric botox in Turkey: sore throat from the endoscope, bloating, nausea, early fullness or constipation. Seek urgent medical help for difficulty swallowing or speaking, drooping eyelids, double or blurred vision, breathlessness or spreading muscle weakness. These can appear weeks later. Tell the doctor that you had intragastric botulinum toxin, and when.
At Vivid Clinic, the main non-surgical alternative is a gastric balloon. It is placed by endoscopy or swallowed as a capsule, and stays in for about 4 to 12 months. It suits adults with a BMI of about 30–40. With a BMI of 40 or more, or 35 with a weight-related illness, a gastric sleeve usually gives more substantial, lasting results. Our medical team reviews your details for free and recommends honestly.
Where it is offered, patients usually fast for around eight hours beforehand. In a hospital endoscopy unit, sedation is given through a cannula, with monitoring throughout. A thin camera passes through the mouth into the stomach. A fine needle then places measured doses into the muscle layer, usually in about 20 to 30 minutes. Patients rest for one to two hours afterwards. Vivid Clinic no longer performs this procedure.
Both are non-surgical and temporary. A gastric balloon has stronger evidence for weight loss, but usually more nausea in the first days. Gastric botox has limited, mixed evidence and is best seen as short-term support to a diet plan. With a BMI of 35 or more, surgery is likely to be far more effective. Vivid Clinic offers the gastric balloon, not gastric botox, and our medical team recommends honestly.
Send your height, weight, medical history and medications. We review the options we offer, not gastric botox. It is free and there is no obligation.
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